Antifungal Effectiveness Test of Cinnamon Extract (Cinnamomum Burmannii) Against Candida Albicans

Main Article Content

Sarah Mersil
Hanna Alifia

Abstract

Background: Candida albicans, is a normal flora that lives on the oral mucosa, digestive tract and vagina. Candida albicans can cause infection such as oral candidiasis. A number of antifungal agents are widely used in the treatment of Candida infections, but some antifungal drugs sometimes have unpleasant side effects. This prompted researchers to examine the contents of natural ingredients that have antifungal activity, one of which is cinnamon. Cinnamon (Cinnamomum burmannii) contains several chemical compounds including cinnamaldehyde and eugenol which are components that have antifungal effects.


Objective: to analyze the effectiveness of cinnamon (Cinnamomum burmannii) antifungal against Candida albicans.


Materials and Methods: The research was performed as laboratory experiment that calculates the diameter of inhibition using the agar-well diffusion method. 25 samples tested were Candida albicans cultured in SDA (Saboroud Dextrose Agar) medium. Variations in treatment concentrations were cinnamon extract (Cinnamomum burmannii) 25%, 50%, 75%, nystatin oral suspension (positive control), and aquades (negative control).


Results: The average inhibition of 75% cinnamon extract (Cinnamomum burmannii) was 16.8 mm, whereas in the positive control nystatin oral suspension was 13.4 mm. The hypothesis test has a value of p=0.000 (p<0.05).


Conclusion: There is an antifungal effectiveness of cinnamon (Cinnamomum burmannii) against Candida albicans at a concentration of 75%.


KEYWORDS: Cinnamon, Cinnamomum burmanni, Candida albicans, Antifungi, Inhibition Zone.

Article Details

How to Cite
Sarah Mersil, & Alifia, H. (2023). Antifungal Effectiveness Test of Cinnamon Extract (Cinnamomum Burmannii) Against Candida Albicans . International Journal of Medical Science and Clinical Research Studies, 3(9), 2013–2017. https://doi.org/10.47191/ijmscrs/v3-i9-39
Section
Articles

References

I. Glick M, Greenberg MS, Lockhart PB, Challacomb SJ. Burket’s Oral Medicine - Michael Glick, Martin S. Greenberg, Peter B. Lockhart, Stephen J. Challacombe - 13th Edition (2021) 1136 Pp., ISBN: 978-1-119-59781-0.; 2021.

II. Dominika D. Minasari. Fungisidal Effect of Cinnamon Extract against Candida albicans and Bactericidal Effect of Bactericidal on Staphylociccus aeureus from Denture Stomatitis. PANMED Scientific Journal.2017:2(1).15-21

III. Laila Nur Rachma. Antifungal Power of Wood Dekok (Cinnamomum burmanni) against Candida albicans In-Vitro. El-Hayah. 2012;3(1):29-34.

IV. Chen P, Sun J, Ford P. Differentiation of the four major species of cinnamons (C. burmannii, C. verum, C. cassia, and C. loureiroi) using a flow injection mass spectrometric (FIMS) fingerprinting method. J Agric Food Chem. 2014;62(12):2516-2521.

V. Winastri NLAP, Muliasari H, Hidayati E. Antibacterial Activity of Juice and Decoction of Calincing (Oxalis corniculata L.) Leaves against Streptococcus mutans. Play Biol. 2020;19(2).223-229.

VI. Milah N, Bintari SH, Mustikaningtyas D. Effect of Antibacterial Concentration of Propolis on the Growth of Streptococcus pyogenes Bacteria in Vitro. Life Science. 2016;6(2):95-99.

VII. Prawitasari H, Yuniwati M. Making Natural Textile Dye Powder from Young Teak Leaf Extract (Tectona Grandis Linn. F) Foam-Mat Drying Method Using Ethanol Solvent. Journal of Process Innovation. 2019;4(1):29-35.

VIII. Paramita N, Trisnadewi I, Pratiwi N, et al. Antifungal Sensitivity Test of Fluconazole and Nystatin to Candida albicans ATCC 10231 Using the Disk Diffusion Method. Udayana Pharmacy Journal. 2016;5(1):8-11.

IX. Mukhriani. Extraction, Separation of Compounds, and Identification of Active Compounds. Health Journal, Faculty of Health Sciences, UIN Alauddin Makassar. 2014;2(2):361-367.

X. Nuryanti S, Jura MR, Nursucianti. Anti-Fungal Activity Test of Cinnamon (Cinnamomum Burmanii Blume) Extract to Candida Albicans Fungi Journal of the Academy of Chemistry. 2015;4(3):123-128.

XI. Dina I, Hussein R. Phytochemical Screening and Nematicidal Activity of Cinnamon and Ginger Extracts Against Root-knot Nematode (Meloidogyne incognita) Infecting Tomato. Egyptian Journal of Agronematology. 2017;16(2):63-84.

XII. Hasanah N, Novian DR. Analysis of Ethanol Extract of Yellow Pumpkin Fruit (Cucurbita Moschata D.). The thinkers of the Pharmaceutical Scientific Journal. 2020;9(1):54-59.

XIII. Yuliani H, Rasyid MI. Effect of Different Solvents on the Toxicity Test of Pineung Nyen Teusale Extract. Indonesian Phytopharmaceutical Journal,. 2019;6(2):347-352.

XIV. XIV. Nurhayati LS, Yahdiyani N, Hidayatulloh A. Comparison of Yogurt Starter Antibacterial Activity Testing with the Well Diffusion Method and the Disc Diffusion Method. Journal of Animal Products Technology. 2020;1(2):41.

XV. Abed AR, Hussein IM. Effect of Cinnamon Extract on Redial Growth of Aspergillus ochraceus and Cellular Growth of Candida albicans. Euphrates Journal of Agriculture Science-. 2015;7(1):23-31.

XVI. Pootong A, Norrapong B, Cowawintaweewat S. Antifungal Activity of Cinnamaldehyde Against Candida albicans. Southeast Asian J Trop Med Public Health. 2017;48(1):150-158.

XVII. XVII. Khatima R, Chotimah C, Fairuz A, Eva. Test of the Inhibitory Power of Cinnamon Extract (Cinnamomum burmannii) on the growth of Candida albicans in Acrylic Dentures. As-Syifaa. 2017;9(2):112-121.

XVIII. Luthfi M, Kriswandini I, Zaba F. Synergistic Effect of The Combination of Cinnamomum burmanii, Vigna unguiculata, and Papain Exracts Derived from Carica Papaya Latex Against C. albicans Biofilms Degradation. Dent J. 2016;49(2):71-75.